In the futuristic year 200X, Dr. Wily seems to have turned over a new leaf and is working with Dr. Light on creating a peace-keeping robot named Gamma. But things take a turn when the eight Robot Masters they designed to protect peace go rogue and steal eight power crystals. It's up to Mega Man, along with his loyal dog Rush, to chase them down across different mining planets in space and recover the crystals.

Adding to the adventure, Proto Man, Dr. Light’s first creation, reappears after a year in hiding. Known as "Blues" in Japan, Proto Man challenges Mega Man in various duels to help him improve his skills. If Mega Man wins, Proto Man opens the way forward. Before the final showdown with Dr. Wily, Proto Man takes on the disguise of "Break Man." Get ready for an exciting journey filled with action and challenges as you help Mega Man save the day!