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I Have No Mouth, and I Must Scream is a point and click adventure game released for MS-DOS in 1995. Developed by The Dreamers Guild and published by Acclaim Entertainment, it is a licensed title based on the works of author Harlan Ellison. The game presents a dark science fiction and cyberpunk narrative viewed from a third person perspective, incorporating significant puzzle elements into its structure.

Players control one of five human survivors in a post apocalyptic world ruled by a malicious artificial intelligence called AM. The objective is to guide each character through a personalized virtual scenario designed by AM to exploit their deepest fears and psychological weaknesses. Progression is structured across six distinct stories, with players needing to complete all of them to conclude the game. Core gameplay involves exploring detailed environments, interacting with objects and characters, and solving logic based puzzles to advance each narrative. The choices made by the player during these adventures can influence the outcome, with different conclusions possible based on the actions taken.

The game's scenarios are varied, including locations such as an iron zeppelin, an Egyptian pyramid, a medieval castle, a jungle, and a concentration camp. Each setting is populated by characters that may be manifestations of AM, figures from the protagonists' pasts, or other entities. A key gameplay system involves navigating these hostile environments and making decisions that test each character's moral resolve and capacity for self forgiveness. The narrative is advanced through dialogue and environmental interaction, with voice work provided by Harlan Ellison as the character AM.